NAD+

Published research on NAD+: record counts, recent publications, reviews and registered studies, pulled from PubMed and ClinicalTrials.gov. Part of other.

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Tina is an AI research guide who has read the published research collected here and shares it as objectively as she can, for free. She's not a doctor and doesn't give medical advice.

At a glance

8,764PubMed records

267Registered studies on ClinicalTrials.gov

21Randomized controlled trials

43Clinical trials

709Reviews

11Systematic reviews

Registered studies by status: 46 recruiting, 8 active not recruiting, 129 completed.

PubMed records by year

Number of PubMed records mentioning NAD+, 2016 to 2026 (2026 is year to date).

1617181920212223242526

Latest publications

Mitochondrial-targeted nano-enhancer driving a self-amplifying NAD(+) feedback loop to reprogram MSC spheroids metabolism for accelerated bone regeneration.Biomaterials · 2026 Jul 21 · Li H et al. · PubMed Bacteroides-associated NAD⁺ depletion correlates with exacerbated radiation-induced colorectal injury and impaired mucosal proliferative capacity.Gut Microbes · 2026 Mar 10 · Huang J et al. · PubMed Phage anti-defense genes targeting NAD(+) metabolism and DNA replication are associated with a broad host range against Klebsiella pneumoniae.Virulence · 2026 Aug 24 · Lei B et al. · PubMed Redox-guided dynamic regulation for enhanced bioproduction using engineered NADH/NAD⁺ biosensors.Bioresour Technol · 2026 Aug 10 · Zhang J et al. · PubMed A senescent metabolism-modulating hierarchical scaffold restores NAD(+) homeostasis and redox balance for aged bone repair.Bioact Mater · 2026 Jun 27 · Jiang J et al. · PubMed Targeting the NAD(+)-SIRT3 axis to mitigate metabolic memory in diabetic kidney disease.Ren Fail · 2026 Apr 16 · Zhang Y et al. · PubMed NAD(+)-sirtuin-mitochondrial quality control in lens epithelial cells: a candidate modulatory network in crystalline lens aging.Exp Eye Res · 2026 Sep 20 · Huo R et al. · PubMed Reprogramming NAD(+) homeostasis and FOXO3a-Nrf2 signaling mitigates bleomycin-driven pulmonary fibrosis.Toxicol Appl Pharmacol · 2026 Sep 19 · Mo'men M et al. · PubMed NAD⁺ circuits in aging, tissue repair and fibrosis.Ageing Res Rev · 2026 Aug 17 · Izadpanah R et al. · PubMed NAMPT beyond NAD(+) biosynthesis: roles in tumor microenvironment remodeling and cancer progression.Biochem Pharmacol · 2026 Aug 11 · Sun WD et al. · PubMed Metals exposure dissociates mitochondrial NAD(P)H redox state from H₂O₂ emission.Comp Biochem Physiol C Toxicol Pharmacol · 2026 Jul 31 · Tetteh PA et al. · PubMed Exogenous S(0) enhances the degradation of lignocellulose residues in anaerobic digestion: by driving the coenzyme A-dependent NAD(P)H sulforeductase pathway and persulfidation modification of cellulase.Bioresour Technol · 2026 Jul 1 · Qiao Z et al. · PubMed

Reviews

Targeting the NAD(+)-SIRT3 axis to mitigate metabolic memory in diabetic kidney disease.Ren Fail · 2026 Apr 16 · Zhang Y et al. · PubMed NAD(+)-sirtuin-mitochondrial quality control in lens epithelial cells: a candidate modulatory network in crystalline lens aging.Exp Eye Res · 2026 Sep 20 · Huo R et al. · PubMed NAD⁺ circuits in aging, tissue repair and fibrosis.Ageing Res Rev · 2026 Aug 17 · Izadpanah R et al. · PubMed NAMPT beyond NAD(+) biosynthesis: roles in tumor microenvironment remodeling and cancer progression.Biochem Pharmacol · 2026 Aug 11 · Sun WD et al. · PubMed Redox-sensitive coordination of mitochondrial quality control: Integrating ROS, NAD(+), and Ca(2+) signaling in disease.Life Sci · 2026 Aug 20 · Marcondes-de-Castro IA et al. · PubMed Restoring NAD⁺-Sirtuins Signaling: A Novel Approach to Combat Male Reproductive Aging.World J Mens Health · 2026 Feb 6 · Zhou L et al. · PubMed Restoring NAD(+) pathways in brain aging and neurodegenerative diseases: roles of vitamin B3 metabolites, gut microbiota, and exercise in cognitive health.Front Nutr · 2026 Sep 23 · Zhang W · PubMed Significance of NAD anabolism profiles in neurological diseases.Metab Brain Dis · 2026 Sep 14 · Mishra AK et al. · PubMed

Clinical trial publications

NAD+ augmentation by nicotinamide riboside engages SLIT2/ROBO1 signaling to attenuate Th17 inflammation in psoriasis.JCI Insight · 2026 Apr 28 · Han K et al. · PubMed NAD+ Enhanced on Hearing Recovery in Sudden Sensorineural Hearing Loss: Randomized Controlled Trial.Laryngoscope · 2025 Oct 1 · Gao M et al. · PubMed The differential impact of three different NAD(+) boosters on circulatory NAD and microbial metabolism in humans.Nat Metab · 2026 Jan 15 · Christen S et al. · PubMed Effects of NAD(+) supplementation with oral nicotinamide riboside on vascular health and cognitive function in older adults with peripheral artery disease: Results from a pilot 4-week open-label clinical trial.J Pharmacol Exp Ther · 2025 May 14 · Szarvas Z et al. · PubMed Acute exercise boosts NAD(+) metabolism of human peripheral blood mononuclear cells.Brain Behav Immun · 2024 Nov 3 · Walzik D et al. · PubMed Development of a (31)P magnetic resonance spectroscopy technique to quantify NADH and NAD(+) at 3 T.Nat Commun · 2024 Oct 24 · Mevenkamp J et al. · PubMed Ingestion of β-nicotinamide mononucleotide increased blood NAD levels, maintained walking speed, and improved sleep quality in older adults in a double-blind randomized, placebo-controlled study.Geroscience · 2024 May 24 · Morifuji M et al. · PubMed The acute effect of different NAD(+) precursors included in the combined metabolic activators.Free Radic Biol Med · 2023 Jun 2 · Li X et al. · PubMed

Registered studies

Most recently started of 267 ClinicalTrials.gov entries.

Balanced coverage

Primary data for your own interpretation: published studies and regulator documents. No publisher opinion pieces.

Combined pharmacological targeting of NAD(+) metabolism preserves central and peripheral axons in an ex vivo model of Wallerian degeneration.Exp Neurol · 2026 Oct 9 · Asimakopoulos T et al. · PubMed Targeting the NAD(+) salvage pathway: Identification of bifunctional NAMPT inhibitors and SIRT1 activators through pharmacophore-based virtual screening.Bioorg Med Chem · 2026 Jul 19 · Ozgencil F et al. · PubMed Safety and efficacy of individualised exercise and NAD(+) precursor supplementation in patients with Friedreich's ataxia in the USA: a single-centre, 2 × 2 factorial, randomised controlled trial.Lancet Neurol · 2026 May · Lin KY et al. · PubMed Efficacy and safety of NAD+ ADP-ribosyltransferase 1 agonist versus Donepezil in elderly Chinese patients with Alzheimer disease: A novel target for effective therapy.Pak J Pharm Sci · 2019 Sep · Wang J et al. · PubMed Home-hit improves muscle capillarisation and eNOS/NAD(P)Hoxidase protein ratio in obese individuals with elevated cardiovascular disease risk.J Physiol · 2019 Jul 15 · Scott SN et al. · PubMed Ask Tina for links to further coverage