Melanotan II

Published research on Melanotan II: record counts, recent publications, reviews and registered studies, pulled from PubMed and ClinicalTrials.gov. Part of other.

Ask Tina

Tina is an AI research guide who has read the published research collected here and shares it as objectively as she can, for free. She's not a doctor and doesn't give medical advice.

At a glance

196PubMed records

1Registered studies on ClinicalTrials.gov

1Randomized controlled trials

4Clinical trials

10Reviews

0Systematic reviews

Registered studies by status: 1 recruiting, 0 active not recruiting, 0 completed.

PubMed records by year

Number of PubMed records mentioning Melanotan II, 2016 to 2026 (2026 is year to date).

1617181920212223242526

Latest publications

Antidepressant-like and antistress effects of the ACTH(4-10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress.Eur J Pharmacol · 2024 Oct 21 · Inozemtseva LS et al. · PubMed Recommended Tool Compounds for the Melanocortin Receptor (MCR) G Protein-Coupled Receptors (GPCRs).ACS Pharmacol Transl Sci · 2024 Aug 26 · Weirath NA et al. · PubMed Multiple metabolic signals in the CeA regulate feeding: The role of AMPK.Mol Cell Endocrinol · 2024 Apr 10 · Castro G et al. · PubMed Therapeutic Strategies Against Metabolic Imbalance in a Male Mouse Model With 5-HT2CR Loss-of-Function.Endocrinology · 2024 May 27 · Liu H et al. · PubMed 5-Hydroxypyrroloindoline Affords Tryptathionine and 2,2'-bis-Indole Peptide Staples: Application to Melanotan-II.Chemistry · 2024 Feb 15 · Todorovic M et al. · PubMed Melanocortin agonism in a social context selectively activates nucleus accumbens in an oxytocin-dependent manner.Neuropharmacology · 2024 Jan 20 · Ford CL et al. · PubMed Obesity medication lorcaserin activates brainstem GLP-1 neurons to reduce food intake and augments GLP-1 receptor agonist induced appetite suppression.Mol Metab · 2022 Dec 30 · Wagner S et al. · PubMed Melanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens decreases appetitive and consumptive responding for food.Neuropeptides · 2022 Sep 16 · Eliason NL et al. · PubMed Vasopressin neurons in the paraventricular hypothalamus promote wakefulness via lateral hypothalamic orexin neurons.Curr Biol · 2022 Jul 30 · Islam MT et al. · PubMed CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists.J Med Chem · 2022 Feb 21 · Tomassi S et al. · PubMed Intracerebroventricular administration of α-melanocyte-stimulating hormone (α-MSH) enhances thigmotaxis and induces anxiety-like behavior in the goldfish Carassius auratus.Peptides · 2021 Aug 8 · Watanabe K et al. · PubMed A sentinel population: The public health benefits of monitoring enhanced body builders.Int J Drug Policy · 2020 Sep 8 · McVeigh J et al. · PubMed

Reviews

Melanocortin receptor agonists in the treatment of male and female sexual dysfunctions: results from basic research and clinical studies.Expert Opin Investig Drugs · 2014 Aug 6 · Ückert S et al. · PubMed Recent advances in porous silicon technology for drug delivery.Ther Deliv · 2013 Jul · Barnes TJ et al. · PubMed Sympathetic and sensory innervation of brown adipose tissue.Int J Obes (Lond) · 2010 Oct · Bartness TJ et al. · PubMed Melanocortin peptide therapeutics: historical milestones, clinical studies and commercialization.Peptides · 2006 Jan 18 · Hadley ME et al. · PubMed Discovery that a melanocortin regulates sexual functions in male and female humans.Peptides · 2005 Oct · Hadley ME · PubMed Central nervous system agents in the treatment of erectile dysfunction: how do they work?Curr Urol Rep · 2001 Dec · Allard J et al. · PubMed

Clinical trial publications

Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II.Int J Impot Res · 2000 Oct · Wessells H et al. · PubMed Effect of an alpha-melanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction.Urology · 2000 Oct 1 · Wessells H et al. · PubMed Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: double-blind, placebo controlled crossover study.J Urol · 1998 Aug · Wessells H et al. · PubMed Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study.Life Sci · 1996 · Dorr RT et al. · PubMed

Registered studies

Most recently started of 1 ClinicalTrials.gov entries.

Melanotan II (MT-II) as an Adjunct to NB-UVB Phototherapy for Repigmentation in Stable Nonsegmental VitiligoNCT07437560 · Recruiting · Phase 2 · started 2026-02-02

Balanced coverage

Primary data for your own interpretation: published studies and regulator documents. No publisher opinion pieces.

Dangers of Injectable Peptides and Other Unregulated "Biohacking" Drugs.Mo Med · 2026 Jul-Aug · Moiz A et al. · PubMed Pharmacological chaperone action in humanized mouse models of MC4R-linked obesity.JCI Insight · 2021 Feb 22 · René P et al. · PubMed Falsification of biotechnology drugs: current dangers and/or future disasters?J Pharm Biomed Anal · 2018 Aug 20 · Janvier S et al. · PubMed Ask Tina for links to further coverage