Hypnotic Dose › Peptides › Acetyl hexapeptide-8 / Argireline Acetyl hexapeptide-8 / Argireline Published research on Acetyl hexapeptide-8 / Argireline: record counts, recent publications, reviews and registered studies, pulled from PubMed and ClinicalTrials.gov. Part of other.
Ask Tina Tina is an AI research guide who has read the published research collected here and shares it as objectively as she can, for free. She's not a doctor and doesn't give medical advice.
At a glance 40 PubMed records
6 Registered studies on ClinicalTrials.gov
2 Randomized controlled trials
2 Clinical trials
3 Reviews
1 Systematic reviews
Registered studies by status: 0 recruiting, 0 active not recruiting, 5 completed.
PubMed records by year Number of PubMed records mentioning Acetyl hexapeptide-8 / Argireline, 2016 to 2026 (2026 is year to date).
16 17 18 19 20 21 22 23 24 25 26
Latest publications DES-mediated self-assembled polypeptides: Synergistic neuromuscular signaling inhibition for anti-aging. Biomater Adv · 2026 May 20 · Bai D et al. · PubMed The effect of a serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate and gluconolactone on skin biomarkers, wrinkles and skin texture: Ex vivo and clinical studies. Int J Cosmet Sci · 2026 Feb 11 · Zhu M et al. · PubMed Mechanistic understanding and peptide ingredient screening for type III collagen via biological knowledge graph and molecular docking. Int J Cosmet Sci · 2026 Sep 2 · Zang S et al. · PubMed Effects of Botulinum Toxin Type A and Argireline on Dermal Collagen Remodeling and Skin Biology in a Flap Model. Aesthetic Plast Surg · 2026 Aug 31 · Acuner B et al. · PubMed Cosmetic potential of Ganoderma lucidum (Reishi) extract in a topical cream formulation. Int J Cosmet Sci · 2026 Feb 9 · Dikmen Kucuk S et al. · PubMed Ex Vivo Evaluation of Skin Permeability Enhancement Using TargetCool in Human-Derived Skin Tissue Models. J Craniofac Surg · 2026 May 5 · Yi KH et al. · PubMed Fluorous oligoarginines as supra-enhancers for intracellular and transdermal peptide delivery. Bioact Mater · 2025 Dec 30 · Rong G et al. · PubMed Thermostable hyaluronic acid-based dissolving microneedles with high-loading capacity: design, optimization, and transdermal delivery of anti-aging ingredients. Int J Biol Macromol · 2026 Feb 3 · Feng M et al. · PubMed Dual-function supramolecular system of α-hydroxy acid-based ionic liquids and peptides for enhanced anti-aging transdermal delivery. J Mater Chem B · 2025 Jul 30 · Wang Z et al. · PubMed Oligomeric hyaluronic acid-modified liposomes effectively improved skin permeability and anti-ageing activity of ellagic acid. Sci Rep · 2025 Jul 26 · Yang X et al. · PubMed A Supramolecular System of Bioactive Ionic Liquid, Peony Extract, and Peptide for Enhanced Permeability and Synergistic Skincare Benefits. Chemistry · 2025 Jul 7 · Wang M et al. · PubMed Acetyl Hexapeptide-8 in Cosmeceuticals-A Review of Skin Permeability and Efficacy. Int J Mol Sci · 2025 Jun 14 · Zdrada-Nowak J et al. · PubMed Reviews Acetyl Hexapeptide-8 in Cosmeceuticals-A Review of Skin Permeability and Efficacy. Int J Mol Sci · 2025 Jun 14 · Zdrada-Nowak J et al. · PubMed Cosmeceuticals in photoaging: A review. Skin Res Technol · 2024 Sep · Chan LKW et al. · PubMed Clinical trial publications The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study. Am J Clin Dermatol · 2013 Apr · Wang Y et al. · PubMed Pilot study of topical acetyl hexapeptide-8 in the treatment for blepharospasm in patients receiving botulinum toxin therapy. Eur J Neurol · 2012 Nov 12 · Lungu C et al. · PubMed Registered studies Most recently started of 6 ClinicalTrials.gov entries.
A Clinical Trial to Evaluate the Effects of an Eye Serum on Improving the Appearance of the Periorbital Area NCT06143033 · Completed · NA · started 2023-08-21 Investigating the Wrinkle Reduction Potential of a Novel Compounded Skin Care Cream NCT03878381 · Completed · EARLY_Phase 1 · started 2019-04-01 Topical Acetyl Hexapeptide-8 and the Cosmetic Appearance of Oily Skin NCT02597777 · Completed · NA · started 2016-01 Acetyl Hexapeptide-8 for Blepharospasm NCT01750346 · Terminated · Phase 2 · started 2012-11 A Study of Acetyl Hexapeptide-8 (AH8) in Treatment of Blepharospasm NCT00942851 · Completed · Phase 1 / Phase 2 · started 2009-07 Argireline in Treatment of Periorbital Wrinkles NCT01381484 · Completed · Phase 3 · started 2009-03 Balanced coverage Primary data for your own interpretation: published studies and regulator documents. No publisher opinion pieces.
Safety Assessment of Acetyl Hexapeptide-8 Amide as Used in Cosmetics. Int J Toxicol · 2025 Jul 17 · Johnson W Jr et al. · PubMed Polydioxanone Bioactive Sutures-Acetyl Hexapeptide-8 (Argireline): An Intelligent System for Controlled Release in Facial Harmonization. J Cutan Aesthet Surg · 2023 Oct-Dec · Velazco de Maldonado GJ et al. · PubMed Complications and adverse effects of periocular aesthetic treatments. Surv Ophthalmol · 2021 Apr 29 · Nagendran ST et al. · PubMed The study of cellular cytotoxicity of argireline - an anti-aging peptide. Acta Biochim Pol · 2014 Mar 17 · Grosicki M et al. · PubMed Ask Tina for links to further coverage Tina is an AI research guide who has read the published research collected here and shares it as objectively as she can, for free. She's not a doctor and doesn't give medical advice.
Search the sources yourself PubMed: Acetyl hexapeptide-8 / Argireline U.S. National Library of Medicine ClinicalTrials.gov: Acetyl hexapeptide-8 / Argireline U.S. National Library of Medicine Related Ask Tina Third-party links, listed for reference. Educational information only, not medical advice. Hypnotic Dose does not endorse any product.