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MOTS-c

Published research on MOTS-c: record counts, recent publications, reviews and registered studies, pulled from PubMed and ClinicalTrials.gov. Part of other.

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Tina is an AI research guide who has read the published research collected here and shares it as objectively as she can, for free. She's not a doctor and doesn't give medical advice.

At a glance

257PubMed records
5Registered studies on ClinicalTrials.gov
4Randomized controlled trials
5Clinical trials
57Reviews
0Systematic reviews

Registered studies by status: 3 recruiting, 1 active not recruiting, 0 completed.

PubMed records by year

Number of PubMed records mentioning MOTS-c, 2016 to 2026 (2026 is year to date).

1617181920212223242526

Latest publications

Mitochondria-derived peptide hydrogel augments mitochondrial transplantation for promoting cardiac repair via macrophage metabolic reprogramming.Bioact Mater · 2026 Aug 14 · Li H et al. · PubMedMOTS-c in sepsis-induced cardiomyopathy: Mechanisms and translational potential.Eur J Pharmacol · 2026 Aug 23 · Zhao Z et al. · PubMedMOTS-c, a mitochondrial-derived peptide, ameliorates lysosomal membrane permeability and improves survival of soft tissue transplantation.Autophagy · 2026 Jun 2 · Shi J et al. · PubMedMOTS-c mediates remote ischemic preconditioning-induced protection against lung ischemia-reperfusion injury via NRF2-dependent mitochondrial biogenesis.Chin Med J (Engl) · 2026 Sep 21 · Sun J et al. · PubMedMitokines as bioenergetic stress signals in cardiovascular disease: mitochondrial communication, endocrine adaptation, and translational implications.J Bioenerg Biomembr · 2026 Sep 14 · Kurian GA · PubMedEmerging regulators of human physiology and disease; sORF-encoded microproteins.Epigenomics · 2026 Aug 10 · Mustafa AM et al. · PubMedMitochondrial-derived peptides (MDPs) activated by physical exercise as therapeutic targets for metabolic disorders: A systematic review.Physiol Int · 2026 Aug 25 · Ayubi N et al. · PubMedMOTS-c is a mitochondrial-encoded interferon-linked host defense peptide.Elife · 2026 Aug 18 · Rice MC et al. · PubMedCirculating mitochondrial-derived microproteins at rest and in response to an acute bout of endurance exercise in individuals with cerebral palsy.Exp Physiol · 2026 Jun 25 · Horwath O et al. · PubMedMitochondrial peptide MOTS-c suppresses systemic and cardiac inflammasome activation in a diabetic rat model.Exp Physiol · 2026 Jun 19 · Mills AR et al. · PubMedMOTS-c attenuates hyperoxia-induced neonatal cardiac injury by inhibiting oxeiptosis via maintaining the KEAP1-PGAM5 interaction.Life Sci · 2026 May 12 · Li SH et al. · PubMedAGEs-RAGE Axis and Mitochondrial-Derived Peptides in Advanced Chronic Kidney Disease: Interconnected Pathways Beyond Inflammation and Nutrition.Antioxidants (Basel) · 2026 Jul 30 · Suliman ME et al. · PubMed

Reviews

MOTS-c in sepsis-induced cardiomyopathy: Mechanisms and translational potential.Eur J Pharmacol · 2026 Aug 23 · Zhao Z et al. · PubMedMitokines as bioenergetic stress signals in cardiovascular disease: mitochondrial communication, endocrine adaptation, and translational implications.J Bioenerg Biomembr · 2026 Sep 14 · Kurian GA · PubMedEmerging regulators of human physiology and disease; sORF-encoded microproteins.Epigenomics · 2026 Aug 10 · Mustafa AM et al. · PubMedMitochondrial-derived peptides (MDPs) activated by physical exercise as therapeutic targets for metabolic disorders: A systematic review.Physiol Int · 2026 Aug 25 · Ayubi N et al. · PubMedMitochondrial dysfunction in ARDS: unraveling the regulatory networks and therapeutic opportunities.Front Immunol · 2026 Jul 29 · Li YH et al. · PubMedMOTS-c: How a secreted mitochondrial microprotein may become a potential treatment for inflammatory lung diseases.J Transl Med · 2026 Jun 4 · Amado CA et al. · PubMedSmall but mighty: mitochondrial DNA at the centre of retrograde signalling.Cell Commun Signal · 2026 Apr 6 · Harding E et al. · PubMedMitochondrial-derived microproteins in lung disease: insights and implications.Am J Physiol Lung Cell Mol Physiol · 2026 Jan 22 · Behan M et al. · PubMed

Clinical trial publications

Repeated Heat Stress Modulates the Levels of the Mitokines MOTS-C and FGF21 in Active Men during Calf Muscle Immobilization.Med Sci Sports Exerc · 2025 Jul 17 · Elhusseiny R et al. · PubMedCirculating levels of MOTS-c in patients with breast cancer treated with metformin.Aging (Albany NY) · 2022 Dec 6 · Cuyàs E et al. · PubMedAcute endurance exercise stimulates circulating levels of mitochondrial-derived peptides in humans.J Appl Physiol (1985) · 2021 Aug 5 · von Walden F et al. · PubMedEffect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors.Sci Rep · 2021 Aug 19 · Dieli-Conwright CM et al. · PubMed

Registered studies

Most recently started of 5 ClinicalTrials.gov entries.

Comparison of the Effects of General Anesthesia and Combined Spinal-Epidural Anesthesia on Ferroptosis, Humanin and MOTS-c Levels in Renal TransplantationNCT07678073 · Recruiting · NA · started 2026-03-01MOTS-c for Improving Insulin Sensitivity in Adults With Prediabetes and Overweight/ObesityNCT07505745 · Recruiting · Phase 2 · started 2026-02-02The Cardiovascular Effect of GLP-1 Agonist, SGLT2 Inhibitor and Their CombinationNCT03878706 · Recruiting · started 2017-11-03Cohort Of DEafness-gene ScreeningNCT06133946 · Active Not Recruiting · started 2016-01-01Platelet Reactivity, B-amyloid, MOTS-c and Mortality of Type II Diabetics With CADNCT04027712 · Unknown · started 2014-01-01

Balanced coverage

Primary data for your own interpretation: published studies and regulator documents. No publisher opinion pieces.

Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance.Sports Med · 2026 Apr 12 · Mendias CL et al. · PubMedSynthetic Peptides in Pharmacy Compounding: Analysis of PCAC Recommendations and Industry Safety Standards.Int J Pharm Compd · 2026 Jul-Aug · Willis J et al. · PubMedMOTS-c in type 2 diabetes mellitus: From risk factors to cardiac complications and potential treatment.Life Sci · 2025 Oct 11 · Fang T et al. · PubMedExercise-Induced Muscle-Fat Crosstalk: Molecular Mediators and Their Pharmacological Modulation for the Maintenance of Metabolic Flexibility in Aging.Pharmaceuticals (Basel) · 2025 Aug 19 · Tero-Vescan A et al. · PubMedβ-Amyloid and mitochondrial-derived peptide-c are additive predictors of adverse outcome to high-on-treatment platelet reactivity in type 2 diabetics with revascularized coronary artery disease.J Thromb Thrombolysis · 2020 Apr · Ikonomidis I et al. · PubMedAsk Tina for links to further coverage

Tina is an AI research guide who has read the published research collected here and shares it as objectively as she can, for free. She's not a doctor and doesn't give medical advice.

Search the sources yourself

PubMed: MOTS-cU.S. National Library of MedicineClinicalTrials.gov: MOTS-cU.S. National Library of Medicine

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