Published research on Melanotan I / afamelanotide: record counts, recent publications, reviews and registered studies, pulled from PubMed and ClinicalTrials.gov. Part of other.
Ask TinaTina is an AI research guide who has read the published research collected here and shares it as objectively as she can, for free. She's not a doctor and doesn't give medical advice.
Registered studies by status: 0 recruiting, 1 active not recruiting, 18 completed.
Number of PubMed records mentioning Melanotan I / afamelanotide, 2016 to 2026 (2026 is year to date).
Most recently started of 23 ClinicalTrials.gov entries.
Pharmacokinetics of Afamelanotide in Erythropoietic Protoporphyria PatientsNCT06388642 · Completed · Phase 1 / Phase 2 · started 2024-03-07A Study to Compare the Efficacy and Safety of SCENESSE and Narrow-Band Ultraviolet (NB-UVB) Light Versus NB-UVB Light Alone in Patients With VitiligoNCT06109649 · Active Not Recruiting · Phase 3 · started 2023-10-11Study to Evaluate the Safety and Efficacy of Afamelanotide in Patients With Variegate Porphyria (VP)NCT05854784 · Completed · Phase 2 · started 2023-03-28A Study to Assess the Changes in Pigmentation and Safety of Afamelanotide in Patients With Vitiligo on the FaceNCT05210582 · Unknown · Phase 2 · started 2022-10-11A Study to Evaluate the Safety and Efficacy of Afamelanotide in Patients With Xeroderma Pigmentosum C and VNCT05370235 · Unknown · Phase 2 · started 2022-03-28DNA Repair Capacity of Afamelanotide on Ultraviolet Radiation-induced DNA Damage in Healthy VolunteersNCT05368857 · Completed · Phase 1 · started 2022-01-19A Study to Evaluate the Safety and Efficacy of Afamelanotide in Patients With Xeroderma Pigmentosum (XP)NCT05159752 · Unknown · Phase 2 · started 2021-10-19A Proof of Concept Study to Evaluate the Safety of Afamelanotide in Patients With Acute Arterial Ischaemic Stroke (AIS)NCT04962503 · Completed · Phase 2 · started 2021-06-03Afamelanotide and Narrow-Band Ultraviolet B (NB-UVB) Phototherapy in the Treatment of Nonsegmental Vitiligo (NSV)NCT04525157 · Completed · Phase 2 · started 2014-06-06Phase III Confirmatory Study in Erythropoietic ProtoporphyriaNCT01605136 · Completed · Phase 3 · started 2012-05Afamelanotide and Narrow-Band Ultraviolet B (NB-UVB) Light in the Treatment of Nonsegmental VitiligoNCT01382589 · Completed · Phase 2 · started 2011-09A Safety Extension Study in Patients With Erythropoietic Protoporphyria (EPP)NCT04578496 · Completed · Phase 3 · started 2011-07-11Primary data for your own interpretation: published studies and regulator documents. No publisher opinion pieces.
New and currently investigated pharmacotherapies for the erythropoietic protoporphyrias: spotlight on dersimelagon and bitopertin.Expert Opin Pharmacother · 2026 Apr 16 · Barman-Aksözen J et al. · PubMedNew pharmacotherapies for the erythropoietic protoporphyrias: an analysis of trial protocols from a patient perspective.Orphanet J Rare Dis · 2025 Dec 29 · Dechant C et al. · PubMedAfamelanotide in managing cutaneous phototoxicity in erythropoietic protoporphyria: a Scottish perspective.Clin Exp Dermatol · 2025 Oct 27 · Dawe RS et al. · PubMedA feasibility and safety study of afamelanotide in acute stroke patients - an open label, proof of concept, phase iia clinical trial.BMC Neurol · 2023 Jul 26 · Stanislaus V et al. · PubMedSkin pigmentation and pharmacokinetics of melanotan-I in humans.Biopharm Drug Dispos · 1997 Apr · Ugwu SO et al. · PubMedAsk Tina for links to further coverageTina is an AI research guide who has read the published research collected here and shares it as objectively as she can, for free. She's not a doctor and doesn't give medical advice.
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