Kisspeptin-10

Published research on Kisspeptin-10: record counts, recent publications, reviews and registered studies, pulled from PubMed and ClinicalTrials.gov. Part of other.

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Tina is an AI research guide who has read the published research collected here and shares it as objectively as she can, for free. She's not a doctor and doesn't give medical advice.

At a glance

316PubMed records

36Registered studies on ClinicalTrials.gov

5Randomized controlled trials

9Clinical trials

13Reviews

0Systematic reviews

Registered studies by status: 5 recruiting, 0 active not recruiting, 23 completed.

PubMed records by year

Number of PubMed records mentioning Kisspeptin-10, 2016 to 2026 (2026 is year to date).

1617181920212223242526

Latest publications

Kisspeptin-10/basal LH ratio improves differentiation of central precocious puberty and premature thelarche.Clin Chim Acta · 2026 Jun 27 · Banerjee AA et al. · PubMed The kisspeptin analog C6 elicits greater tachyphylaxis and transcriptional activation than kisspeptin-10 and -54.Mol Cell Endocrinol · 2026 Jun 30 · Robert V et al. · PubMed Kisspeptin-10 Alleviates Obesity-induced Testicular Oxidative Stress and Mitochondrial Dysfunction via Modulation of Mitophagy and Autophagy Signaling.Reprod Sci · 2026 Sep 28 · Arkalı G et al. · PubMed Enzymatic Stability and Comparative Effects of Kisspeptin-14, Kisspeptin-13 and Kisspeptin-10 on Beta-Cell Function, Glucose Homeostasis and Appetite Regulation.Metabolites · 2026 Sep 17 · Spratt JA et al. · PubMed Maternal Kisspeptin-10 Treatment Partially Rescues Fetal and Postnatal Cardiac Programming Disrupted by Maternal Hypothyroidism.Cardiovasc Toxicol · 2026 Sep 11 · Barbosa EM et al. · PubMed Structural basis for Kisspeptin-10 selectivity toward KISS1R: computational insights.In Silico Pharmacol · 2026 Sep 6 · Netesa MA et al. · PubMed Kisspeptin System: A Modulator of Neuroinflammation and Behaviour in Temporal Lobe Epileptic Rats.Mol Neurobiol · 2026 Sep 1 · Jaldhi et al. · PubMed Chronic subcutaneous kisspeptin-10 stimulates gonadotropin secretion for 12 days in healthy men.Eur J Endocrinol · 2026 Aug 3 · Yeung AC et al. · PubMed Exogenous Kisspeptin-10 inhibits ovarian cancer progression through targeting the SP1-hTERT-ZEB1 regulatory axis.Cytotechnology · 2026 Jun 11 · Shah H et al. · PubMed Kisspeptin-10 regulates glycosaminoglycan and decorin content in human cardiac fibroblast cultures.Pharmacol Rep · 2026 May 20 · Radwańska P et al. · PubMed Deciphering protein-DNA interactions of KISS1 with transcription factors through molecular docking, molecular dynamics simulations, and gene expression analysis.J Biomol Struct Dyn · 2025 Sep 5 · Shah H et al. · PubMed Dynamic modulation of LH secretion by continuous kisspeptin infusion in healthy men.Hormones (Athens) · 2026 Jun 2 · Naveed A et al. · PubMed

Reviews

The KISS1/KISS1R Axis in Human Placentation: Molecular Mechanisms and Implications for Foetal Growth Restriction and Pre-Eclampsia.Int J Mol Sci · 2026 Apr 23 · Gyokova E et al. · PubMed The roles of kisspeptin and neurokinin B in GnRH pulse generation in humans, and their potential clinical application.J Neuroendocrinol · 2021 Dec 28 · Anderson RA et al. · PubMed The KiSS-1/GPR54 system: Essential roles in physiological homeostasis and cancer biology.Genes Dis · 2020 Jul 24 · Zhu N et al. · PubMed Roles of the kisspeptin/GPR54 system in pathomechanisms of atherosclerosis.Nutr Metab Cardiovasc Dis · 2020 Mar 7 · Watanabe T et al. · PubMed KISS1 in breast cancer progression and autophagy.Cancer Metastasis Rev · 2019 Sep · Ulasov IV et al. · PubMed Role of Kisspeptin and NKB in Puberty in Nonhuman Primates: Sex Differences.Semin Reprod Med · 2019 Dec 17 · Garcia JP et al. · PubMed [Advances in the study of neuroendocrinological regulation of kisspeptin in fish reproduction].Dongwuxue Yanjiu · 2013 Oct · Zhuo Q · PubMed The Kiss-1/Kiss-1R complex as a negative regulator of cell motility and cancer metastasis (Review).Int J Mol Med · 2013 Aug 21 · Ji K et al. · PubMed

Clinical trial publications

Chronic subcutaneous kisspeptin-10 stimulates gonadotropin secretion for 12 days in healthy men.Eur J Endocrinol · 2026 Aug 3 · Yeung AC et al. · PubMed Kisspeptin and neurokinin B interactions in modulating gonadotropin secretion in women with polycystic ovary syndrome.Hum Reprod · 2020 Jun 1 · Skorupskaite K et al. · PubMed Age-dependent changes in the reproductive axis responsiveness to kisspeptin-10 administration in healthy men.Andrologia · 2018 Dec 27 · Ullah H et al. · PubMed Interactions Between Neurokinin B and Kisspeptin in Mediating Estrogen Feedback in Healthy Women.J Clin Endocrinol Metab · 2016 Sep 16 · Skorupskaite K et al. · PubMed Exploring the pathophysiology of hypogonadism in men with type 2 diabetes: kisspeptin-10 stimulates serum testosterone and LH secretion in men with type 2 diabetes and mild biochemical hypogonadism.Clin Endocrinol (Oxf) · 2013 Apr 19 · George JT et al. · PubMed Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men.J Clin Endocrinol Metab · 2011 Jun 1 · George JT et al. · PubMed Characteristics of stimulation of gonadotropin secretion by kisspeptin-10 in female goats.Anim Reprod Sci · 2010 Mar · Hashizume T et al. · PubMed An increase in kisspeptin-54 release occurs with the pubertal increase in luteinizing hormone-releasing hormone-1 release in the stalk-median eminence of female rhesus monkeys in vivo.Endocrinology · 2008 May 1 · Keen KL et al. · PubMed

Registered studies

Most recently started of 36 ClinicalTrials.gov entries.

Kisspeptin to Quantify GnRH Neuronal Function in Health and DiseaseNCT07224490 · Recruiting · Phase 1 · started 2026-03-10 Kisspeptin Administration Subcutaneously to Patients With Hypothalamic AmenorrheaNCT07224438 · Recruiting · Phase 2 · started 2025-12-09 Functional Proteins in Polycystic Ovary SyndromeNCT06793098 · Recruiting · started 2025-01-20 Kissing as a Protective Factor Against Acidic pH in SalivaNCT06501729 · Completed · NA · started 2024-07-30 A Prospective Cohort Study on the Serum Kisspeptin Levels Throughout Pregnancy in PCOSNCT06545994 · Unknown · started 2024-06-28 Recall by Genotype: Neuropeptide StimulationNCT05901467 · Terminated · Phase 1 · started 2023-10-20 Dampening the Reproductive Axis With Continuous KisspeptinNCT05971849 · Completed · Phase 1 · started 2023-10-06 Evaluation of Some Puberty-related Hormones Among Children and Adolescents With Chronic Kidney DiseasesNCT05835089 · Unknown · started 2023-05 Kisspeptin Administration Subcutaneously to Patients With IHHNCT05896293 · Recruiting · Phase 2 · started 2023-02-03 Kisspeptin Administration Subcutaneously to Patients With Reproductive DisordersNCT05633966 · Completed · Phase 1 · started 2022-12-16 Evaluation of Kisspeptin Stimulated Insulin Secretion With Hyperglycemic ClampNCT05456854 · Withdrawn · Phase 1 · started 2022-06-03 Evaluation of Kisspeptin Glucose-Stimulated Insulin Secretion With Oral Glucose Tolerance TestNCT04958109 · Completed · Phase 1 · started 2021-10-28

Balanced coverage

Primary data for your own interpretation: published studies and regulator documents. No publisher opinion pieces.

Rapid and harmonized analytical workflow for the determination of peptidic and non-peptidic doping agents in dried and liquid blood matrices.Analyst · 2026 Jul 27 · Mazzarino M et al. · PubMed Synthesis and characterisation of DOTA-kisspeptin-10 as a potential gallium-68/lutetium-177 pan-tumour radiopharmaceutical.J Neuroendocrinol · 2025 Jan 7 · Kleynhans J et al. · PubMed Ask Tina for links to further coverage