Published research on Tirzepatide: record counts, recent publications, reviews and registered studies, pulled from PubMed and ClinicalTrials.gov. Part of metabolic research.
Ask TinaTina is an AI research guide who has read the published research collected here and shares it as objectively as she can, for free. She's not a doctor and doesn't give medical advice.
Registered studies by status: 98 recruiting, 32 active not recruiting, 91 completed.
Number of PubMed records mentioning Tirzepatide, 2016 to 2026 (2026 is year to date).
Most recently started of 298 ClinicalTrials.gov entries.
Tirzepatide for the Treatment of Cannabis Use DisorderNCT07265752 · Not Yet Recruiting · Phase 2 · started 2027-03-01Effects of Tirzepatide on Gut Microbiota and Gastrointestinal Function After Drug Withdrawal in Obese PatientsNCT07847515 · Not Yet Recruiting · started 2027-02-01GLP-1/GIP Receptor Agonists in Obesity-Related HFpEF: The GLIDE-HF RegistryNCT07787936 · Not Yet Recruiting · started 2027-01-01Tirzepatide in Women With Obesity and Endometrial Intra-epithelial Neoplasia or Grade 1 Endometrial CancerNCT07078838 · Not Yet Recruiting · Phase 2 · started 2027-01Preoperative Optimization With Tirzepatide, Ketogenic Diet, or Standard Care Before One Anastomosis Gastric Bypass SurgeryNCT07622992 · Not Yet Recruiting · started 2027-01-01Efficacy of Tirzepatide for Weight Management in Patients With Suboptimal Weight Loss After Bariatric Surgery: A Randomized, Double-Blind, Placebo-Controlled Clinical TrialNCT07829198 · Not Yet Recruiting · Phase 3 · started 2027-01Tirzepatide for the Treatment of Concurrent Type 1 Diabetes and Overweight or ObesityNCT06180616 · Not Yet Recruiting · Phase 2 · started 2026-12Trial of Tirzepatide for the Treatment of Cannabis Use DisorderNCT07468552 · Not Yet Recruiting · Phase 2 · started 2026-11-15SYNCHRONIZE®-START- A Study to Test Whether Survodutide Helps People Living With Overweight or Obesity Who do Not Have Diabetes to Lose WeightNCT07855900 · Not Yet Recruiting · Phase 3 · started 2026-11-07A Study of SYH2069 Injection in Participants With T2DM Not Controlled With Diet/Exercise Alone or MetforminNCT07796477 · Not Yet Recruiting · Phase 2 · started 2026-11-06A Study of Weight Loss Intervention With Tirzepatide and Progestin Intrauterine Device to Treat Endometrial Hyperplasia and Grade 1 Endometrial CancerNCT07349641 · Not Yet Recruiting · Phase 2 · started 2026-11-01Tirzepatide and Levonorgestrel IUD Therapy for EIN and Early-Stage Endometrial CancerNCT07812636 · Not Yet Recruiting · EARLY_Phase 1 · started 2026-11-01Positive coverage and opinions: this section collects news and commentary that read favorably.
Novo's CagriSema delivers superior weight loss versus tirzepatide in REIMAGINE 5 trialNovo Nordisk (via GlobeNewswire) · Sep 21, 2026Primary data for your own interpretation: published studies and regulator documents. No publisher opinion pieces.
Incretin therapy prescription in a high cardiovascular risk population: Insights from a cardiology-based cardiometabolic program.Am J Prev Cardiol · 2026 Jun 6 · Patel A et al. · PubMedOne receptor, two opposite approaches: efficacy and tolerability of GIPR agonism and antagonism in obesity pharmacotherapy.Appetite · 2026 Jul 23 · Gao SX et al. · PubMedCurrent review of glucagon-like peptide 1 receptor agonists and risk of nonarteritic anterior ischemic optic neuropathy.J Endocr Soc · 2026 Oct 1 · Ruan F et al. · PubMedTirzepatide Initiation in Lithium-Treated Bipolar Disorder: Renal Biomarker Trajectories and Lithium Safety Signals Over 12 Months in a Real-World Cohort.Hum Psychopharmacol · 2026 Nov · Rescalli MB et al. · PubMedCardiorenal Mortality and Safety Outcomes of GLP-1 Receptor Agonists in Type 2 Diabetes With BMI Below 27 kg/m(2): A Target Trial Emulation.Diabetes Obes Metab · 2026 Aug 25 · Chen SC et al. · PubMedClinical efficacy of switching to tirzepatide in patients with type 2 diabetes and a high risk of metabolic dysfunction-associated steatotic liver disease undergoing GLP-1 receptor agonist therapy: Insights from the Hokkaido-TZP study.J Diabetes Complications · 2026 Aug 14 · Takiyama T et al. · PubMedLithium and GLP-1-based therapies in bipolar disorder: an emerging pharmacovigilance signal and monitoring considerations.Int Clin Psychopharmacol · 2026 Jul 28 · Cotrik E et al. · PubMedDevelopment and validation of a multiplexed LC-HRMS method for nine GLP-1 receptor agonists and its pharmaceutical application.J Chromatogr A · 2026 Jul 21 · Tong LH et al. · PubMedBidirectional pharmacology of GIP receptor targeting in obesity: Historical foundations, mechanistic divergence, and translational boundaries.Peptides · 2026 Oct 5 · Liu C et al. · PubMedGastrointestinal adverse effects of GLP-1 receptor agonists and dual GIP/GLP-1 receptor agonists: A narrative expert review of approved therapies, oral formulations, and pipeline agents.Nutr Clin Pract · 2026 Oct · Singhani V et al. · PubMedAsk Tina for links to further coverageTina is an AI research guide who has read the published research collected here and shares it as objectively as she can, for free. She's not a doctor and doesn't give medical advice.
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