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Survodutide

Published research on Survodutide: record counts, recent publications, reviews and registered studies, pulled from PubMed and ClinicalTrials.gov. Part of metabolic research.

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Tina is an AI research guide who has read the published research collected here and shares it as objectively as she can, for free. She's not a doctor and doesn't give medical advice.

At a glance

87PubMed records
29Registered studies on ClinicalTrials.gov
9Randomized controlled trials
10Clinical trials
47Reviews
7Systematic reviews

Registered studies by status: 4 recruiting, 3 active not recruiting, 18 completed.

PubMed records by year

Number of PubMed records mentioning Survodutide, 2016 to 2026 (2026 is year to date).

1617181920212223242526

Latest publications

The Power of Two: Harnessing Dual Glucagon and Incretin Signaling for Treatment of Obesity and Metabolic Dysfunction-Associated Steatohepatitis-A Narrative Review with a Translational Focus.Obes Rev · 2026 Oct 11 · Ard JD et al. · PubMedSurvodutide for the treatment of obesity: Mechanistic rationale, clinical evidence, and remaining uncertainties.Contemp Clin Trials · 2026 Oct 2 · Sergi CM · PubMedNephroprotective Effects of the Dual GCGR/GLP-1R Agonist Survodutide in Hypertension-Accelerated Diabetic Kidney Disease.Diabetes Obes Metab · 2026 Oct 1 · Hamilton A et al. · PubMedSurvodutide Once Weekly in Adults with Obesity and Type 2 Diabetes.N Engl J Med · 2026 Oct 1 · Wharton S et al. · PubMedSurvodutide for Obesity in Chinese Adults: Phase 3 Randomized Trial Design and Baseline Characteristics (SYNCHRONIZE™-CN).Diabetes Ther · 2026 Aug 14 · Ji L et al. · PubMed[New Therapeutic Approaches for MASH: Mechanisms and Clinical Promise].Z Gastroenterol · 2026 Sep 23 · Barton A et al. · PubMedMASLD: Established Knowledge and Emerging Directions - Guideline Updates.Z Gastroenterol · 2026 Sep 23 · Roeb E et al. · PubMedDual Glucagon and GLP-1 Receptor Agonist Survodutide Improves Biomarkers of Beta-Cell Function and Insulin Sensitivity in People With Type 2 Diabetes or Living With Overweight/Obesity.Diabetes Obes Metab · 2026 Jun 22 · Ekinci EI et al. · PubMedA review of survodutide: a new dual acting agonist.Minerva Endocrinol (Torino) · 2026 Mar 19 · Yathindra MR et al. · PubMedPathogenesis-Informed Phenotype-Guided Therapy for MASH: A Three-Axis Translational Framework Within the MASLD Spectrum.Biomedicines · 2026 Aug 24 · Zhao Z et al. · PubMedSurvodutide Once Weekly for the Treatment of Adults with Obesity.N Engl J Med · 2026 Jun 7 · le Roux CW et al. · PubMedCardiovascular Effects of Glucagon Receptor Signaling Alone and Combined With Glucagon-Like Peptide-1 Receptor Signaling in Multiagonists: A Narrative Review With a Translational Focus.J Am Heart Assoc · 2026 Jul 31 · Kushner PR et al. · PubMed

Reviews

The Power of Two: Harnessing Dual Glucagon and Incretin Signaling for Treatment of Obesity and Metabolic Dysfunction-Associated Steatohepatitis-A Narrative Review with a Translational Focus.Obes Rev · 2026 Oct 11 · Ard JD et al. · PubMed[New Therapeutic Approaches for MASH: Mechanisms and Clinical Promise].Z Gastroenterol · 2026 Sep 23 · Barton A et al. · PubMedMASLD: Established Knowledge and Emerging Directions - Guideline Updates.Z Gastroenterol · 2026 Sep 23 · Roeb E et al. · PubMedA review of survodutide: a new dual acting agonist.Minerva Endocrinol (Torino) · 2026 Mar 19 · Yathindra MR et al. · PubMedPathogenesis-Informed Phenotype-Guided Therapy for MASH: A Three-Axis Translational Framework Within the MASLD Spectrum.Biomedicines · 2026 Aug 24 · Zhao Z et al. · PubMedCardiovascular Effects of Glucagon Receptor Signaling Alone and Combined With Glucagon-Like Peptide-1 Receptor Signaling in Multiagonists: A Narrative Review With a Translational Focus.J Am Heart Assoc · 2026 Jul 31 · Kushner PR et al. · PubMedAnti-Obesity Medications in Longevity and Aesthetic Medicine.J Clin Med · 2026 Aug 3 · Bijoch J · PubMedBeyond weight loss: multisystem benefits of obesity medications.Lancet Diabetes Endocrinol · 2026 May 28 · Savas M et al. · PubMed

Clinical trial publications

Dual Glucagon and GLP-1 Receptor Agonist Survodutide Improves Biomarkers of Beta-Cell Function and Insulin Sensitivity in People With Type 2 Diabetes or Living With Overweight/Obesity.Diabetes Obes Metab · 2026 Jun 22 · Ekinci EI et al. · PubMedSurvodutide Once Weekly for the Treatment of Adults with Obesity.N Engl J Med · 2026 Jun 7 · le Roux CW et al. · PubMedSurvodutide in adults with obesity and metabolic dysfunction-associated steatotic liver disease: SYNCHRONIZE-MASLD, a randomized, double-blind, placebo-controlled phase 3 trial.Nat Med · 2026 Jun 7 · Kaplan LM et al. · PubMedBaseline characteristics in the SYNCHRONIZE™-2 randomized phase 3 trial of survodutide, a glucagon receptor/GLP-1 receptor dual agonist, for obesity in people with type 2 diabetes.Diabetes Obes Metab · 2025 Nov 11 · Wharton S et al. · PubMedSurvodutide for treatment of obesity: Baseline characteristics of participants in a randomized, double-blind, placebo-controlled, phase 3 trial (SYNCHRONIZE™-1).Diabetes Obes Metab · 2025 Nov 4 · le Roux CW et al. · PubMedSubgroup analysis by sex and baseline BMI in people with a BMI ≥27 kg/m(2) in the phase 2 trial of survodutide, a glucagon/GLP-1 receptor dual agonist.Diabetes Obes Metab · 2025 Jan 16 · le Roux CW et al. · PubMedA Phase 2 Randomized Trial of Survodutide in MASH and Fibrosis.N Engl J Med · 2024 Jun 7 · Sanyal AJ et al. · PubMed

Registered studies

Most recently started of 29 ClinicalTrials.gov entries.

SYNCHRONIZE®-START- A Study to Test Whether Survodutide Helps People Living With Overweight or Obesity Who do Not Have Diabetes to Lose WeightNCT07855900 · Not Yet Recruiting · Phase 3 · started 2026-11-07SYNCHRONIZE®-HERA: A Study to Test Whether Survodutide Helps Women Who Are Living With Overweight or Obesity and Are Going Through or Have Finished Menopause, to Lose WeightNCT07850050 · Not Yet Recruiting · Phase 3 · started 2026-10-31ELEVATE-LIVER: A Study to Test Whether Survodutide Helps Improve Heart Structure and Function in People With Overweight or Obesity and Fatty Liver DiseaseNCT07850063 · Not Yet Recruiting · Phase 3 · started 2026-10-23A Study to Compare How 2 Different Formulations of Survodutide Are Taken up in the Body When Given by Injection in Healthy Men and Women With and Without Overweight or ObesityNCT07768813 · Recruiting · Phase 1 · started 2026-09-02A Study to Test Whether Survodutide Helps People With Type 2 Diabetes Control Their Blood SugarNCT07754461 · Recruiting · Phase 3 · started 2026-08-24A Study in People With Overweight or Obesity to Compare How 2 Different Formulations of Survodutide Are Taken up by the BodyNCT07407348 · Active Not Recruiting · Phase 1 · started 2026-03-11A Study in Healthy People or Otherwise Healthy With Overweight or Obesity to Compare 2 Formulations of Survodutide Given in Different Ways, Either as a Pre-filled Syringe or a Pen-like InjectorNCT07413913 · Completed · Phase 1 · started 2026-03-03Albuminuria Reduction Study With Survodutide Treatment in Kidney DiseaseNCT07206290 · Not Yet Recruiting · Phase 2 · started 2026-03-02A Study in Healthy People to Compare How 2 Different Formulations of Survodutide Are Taken up by the BodyNCT07221591 · Completed · Phase 1 · started 2025-11-05A Study in Healthy People to Compare How 2 Different Formulations of Survodutide Are Taken up in the BodyNCT07071974 · Completed · Phase 1 · started 2025-07-28A Study to Test Whether Survodutide Improves How the Body Uses Energy and Breaks Down Fat in People With ObesityNCT06745284 · Active Not Recruiting · Phase 1 · started 2025-03-26A Study in Healthy People to Compare How 3 Different Formulations of Survodutide Are Taken up in the BodyNCT06772532 · Completed · Phase 1 · started 2025-02-10

Good News

Positive coverage and opinions: this section collects news and commentary that read favorably.

Boehringer Ingelheim’s survodutide achieves up to 13.1% weight loss in new Phase III trial, alongside significant improvements in glycemic control in people with obesity and type 2 diabetesBoehringer Ingelheim (via GlobeNewswire) · Oct 1, 2026

Balanced coverage

Primary data for your own interpretation: published studies and regulator documents. No publisher opinion pieces.

Development and validation of a multiplexed LC-HRMS method for nine GLP-1 receptor agonists and its pharmaceutical application.J Chromatogr A · 2026 Jul 21 · Tong LH et al. · PubMedGastrointestinal adverse effects of GLP-1 receptor agonists and dual GIP/GLP-1 receptor agonists: A narrative expert review of approved therapies, oral formulations, and pipeline agents.Nutr Clin Pract · 2026 Oct · Singhani V et al. · PubMedEfficacy and Safety of Dual GLP-1/Glucagon Receptor Agonism in Overweight and Obesity: A Class-Specific Systematic Review and Meta-Analysis.Diabetes Obes Metab · 2026 Sep 29 · Amjad MM et al. · PubMedRecent Studies on the Effectiveness and Safety of Anti-Obesity Medications: A Scoping Review.Diabetes Metab Syndr Obes · 2026 Sep 2 · Puspitasari IM et al. · PubMedPharmacological management of obesity: Current landscape and emerging therapies.Indian J Pharmacol · 2026 Sep 2 · Atal S et al. · PubMedEfficacy and Safety of Dual and Triple Glucagon-Like Peptide-1-Based Polyagonists in Metabolic Dysfunction-Associated Steatotic Liver Disease and Steatohepatitis: A Systematic Review and Meta-Analysis.Cureus · 2026 Jun 29 · Santos Solis R et al. · PubMedObesity pharmacotherapy reimagined: The era of multi-receptor agonists and next-generation metabolic modulators, perspectives and controversies.Metabol Open · 2026 Mar 23 · Lempesis IG et al. · PubMedEfficacy of pharmacotherapies in improving liver fibrosis among patients with MASLD and fibrosis stages of F1-F3: systematic review and network meta-analysis.J Transl Med · 2026 May 26 · Sun XY et al. · PubMedComparative Efficacy and Safety of Glucagon Receptor Agonists on Metabolic Outcomes: A Network Meta-Analysis of Randomised Controlled Trials.Endocrinol Diabetes Metab · 2026 Mar · Abulehia A et al. · PubMedEfficacy, tolerability and pharmacokinetics of survodutide, a glucagon/glucagon-like peptide-1 receptor dual agonist, in cirrhosis.J Hepatol · 2024 Jun 8 · Lawitz EJ et al. · PubMedAsk Tina for links to further coverage

Tina is an AI research guide who has read the published research collected here and shares it as objectively as she can, for free. She's not a doctor and doesn't give medical advice.

Search the sources yourself

PubMed: SurvodutideU.S. National Library of MedicineClinicalTrials.gov: SurvodutideU.S. National Library of Medicine

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