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Cagrilintide

Published research on Cagrilintide: record counts, recent publications, reviews and registered studies, pulled from PubMed and ClinicalTrials.gov. Part of metabolic research.

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Tina is an AI research guide who has read the published research collected here and shares it as objectively as she can, for free. She's not a doctor and doesn't give medical advice.

At a glance

102PubMed records
44Registered studies on ClinicalTrials.gov
15Randomized controlled trials
15Clinical trials
49Reviews
7Systematic reviews

Registered studies by status: 11 recruiting, 7 active not recruiting, 24 completed.

PubMed records by year

Number of PubMed records mentioning Cagrilintide, 2016 to 2026 (2026 is year to date).

1617181920212223242526

Latest publications

Co-agonism of GLP-1R and CTR/AMYR in the lateral dorsal tegmental nucleus produces additive effects on homeostatic and motivated feeding.Physiol Behav · 2026 Aug 15 · Sanchez-Navarro MJ et al. · PubMedDesign and baseline characteristics of the CagriSema cardiovascular outcomes trial (REDEFINE 3).Am Heart J · 2026 Oct 6 · Cavender MA et al. · PubMedEfficacy of CagriSema for Reaching Anthropometric Treatment Targets and Cardiometabolic Outcomes: A Secondary, Post hoc Analysis of REDEFINE 1.Diabetes Obes Metab · 2026 Jul 26 · Busetto L et al. · PubMedNew Amylin-Based Agonists for the Treatment of Obesity and Type 2 Diabetes Mellitus.Diabetes Ther · 2026 Sep 28 · Panou T et al. · PubMedCagrilintide and retatrutide combination therapy enhances weight loss and metabolic outcomes in obese male rats.Nat Metab · 2026 Sep 15 · Petersen J et al. · PubMedAmylin Analogs: The Next Major Class of Weight Loss Therapy: A Review of Experimental Data and Early-Phase Clinical Trials.Diabetes Obes Metab · 2026 Jul 14 · Alhazmi A et al. · PubMedMaximizing weight loss with cagrisema: a systematic review and GRADE-assessed meta-analysis of randomized controlled trials.Naunyn Schmiedebergs Arch Pharmacol · 2026 Aug 17 · Khan BW et al. · PubMedAmylin-based obesity therapy: a meta-analysis of Cagrilintide and CagriSema versus placebo.Ann Med Surg (Lond) · 2026 Jul 13 · Yaseen M et al. · PubMedDistinct brain regions mediate regulation of food intake in response to GIPR agonism or antagonism.Nat Metab · 2026 Jul 24 · Lewis JE et al. · PubMedCagrilintide-semaglutide (CagriSema) versus semaglutide or cagrilintide in people with type 2 diabetes (REIMAGINE 2): a double-blind, randomised, controlled, phase 3 study.Lancet Diabetes Endocrinol · 2026 Jun 7 · Buse JB et al. · PubMedCagrilintide-semaglutide: a new option for patients with type 2 diabetes.Lancet Diabetes Endocrinol · 2026 Jun 7 · Scheen AJ · PubMedBeyond weight loss: multisystem benefits of obesity medications.Lancet Diabetes Endocrinol · 2026 May 28 · Savas M et al. · PubMed

Reviews

New Amylin-Based Agonists for the Treatment of Obesity and Type 2 Diabetes Mellitus.Diabetes Ther · 2026 Sep 28 · Panou T et al. · PubMedAmylin Analogs: The Next Major Class of Weight Loss Therapy: A Review of Experimental Data and Early-Phase Clinical Trials.Diabetes Obes Metab · 2026 Jul 14 · Alhazmi A et al. · PubMedMaximizing weight loss with cagrisema: a systematic review and GRADE-assessed meta-analysis of randomized controlled trials.Naunyn Schmiedebergs Arch Pharmacol · 2026 Aug 17 · Khan BW et al. · PubMedBeyond weight loss: multisystem benefits of obesity medications.Lancet Diabetes Endocrinol · 2026 May 28 · Savas M et al. · PubMedComparative effects of drugs for adults with overweight or obesity: systematic review and network meta-analysis.BMJ · 2026 Jul 8 · Nong K et al. · PubMedCagriSema Versus Semaglutide Monotherapy or Placebo for Obesity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with GRADE Assessment.Am J Cardiol · 2026 Feb 26 · Gadelmawla AF et al. · PubMedNovel Amylin-Based Therapies for Weight Management in Adults With Overweight or Obesity Without Diabetes: A Network Meta-Analysis.Endocrinol Diabetes Metab · 2026 May · Kamrul-Hasan ABM et al. · PubMedNew Drugs on the Block: Dietary Management and Nutritional Considerations During the Use of Anti-Obesity Medication.Nutrients · 2026 Mar 18 · Pardali EC et al. · PubMed

Clinical trial publications

Efficacy of CagriSema for Reaching Anthropometric Treatment Targets and Cardiometabolic Outcomes: A Secondary, Post hoc Analysis of REDEFINE 1.Diabetes Obes Metab · 2026 Jul 26 · Busetto L et al. · PubMedCagrilintide-semaglutide (CagriSema) versus semaglutide or cagrilintide in people with type 2 diabetes (REIMAGINE 2): a double-blind, randomised, controlled, phase 3 study.Lancet Diabetes Endocrinol · 2026 Jun 7 · Buse JB et al. · PubMedCagrilintide-semaglutide (CagriSema) as an add-on to basal insulin in adults with type 2 diabetes (REIMAGINE 3): a randomised, double-blind, placebo-controlled, multicentre, phase 3 study.Lancet · 2026 Jun 7 · Rosenstock J et al. · PubMedCagriSema Reduces Blood Pressure in Adults With Overweight or Obesity: REDEFINE 1.Hypertension · 2025 Dec 2 · Verma S et al. · PubMedEloralintide (LY3841136), a novel amylin receptor agonist for the treatment of obesity: From discovery to clinical proof of concept.Mol Metab · 2025 Oct 16 · Briere DA et al. · PubMedCoadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity.N Engl J Med · 2025 Jun 22 · Garvey WT et al. · PubMedCagrilintide-Semaglutide in Adults with Overweight or Obesity and Type 2 Diabetes.N Engl J Med · 2025 Jun 22 · Davies MJ et al. · PubMedCagrilintide is not associated with clinically relevant QTc prolongation: A thorough QT study in healthy participants.Diabetes Obes Metab · 2024 Sep 16 · Gabe MBN et al. · PubMed

Registered studies

Most recently started of 44 ClinicalTrials.gov entries.

Research Study on How People With Type 2 Diabetes Tolerate Switching From Semaglutide to CagrisemaNCT07817251 · Recruiting · Phase 3 · started 2026-09-16A Research Study to Compare Two Different Versions of Injectable CagriSema in People With Type 2 DiabetesNCT07357740 · Withdrawn · Phase 2 · started 2026-08-27A Research Study to Compare Two Different Versions of Injectable Cagrilintide and Placebo in People With Excess Body WeightNCT07745504 · Recruiting · Phase 3 · started 2026-08-04A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in Children and Adolescents With Type 2 DiabetesNCT07282613 · Recruiting · Phase 3 · started 2026-08-04A Research Study to Compare Different Versions of Injectable CagriSema and Placebo in People With Excess Body WeightNCT07357766 · Withdrawn · Phase 3 · started 2026-06-22Evaluation of the Tolerability of Cagrilintide in Participants Not Tolerating GLP-1-RA Therapies Due to Gastrointestinal Adverse EventsNCT07607587 · Recruiting · Phase 1 · started 2026-05-29A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose WeightNCT07564414 · Recruiting · Phase 3 · started 2026-05-21A Research Study to Compare Blood Levels of Two Different Versions of Cagrilintide in Adults With Excess Body WeightNCT07605052 · Completed · Phase 1 · started 2026-05-20A Research Study to Compare Blood Levels of Cagrilintide After Multiple Doses of Different Versions of Cagrilintide in Adults With Overweight or ObesityNCT07597018 · Recruiting · Phase 1 · started 2026-05-18A Research Study Looking Into How Cagrilintide Influences Food Intake and Appetite in People With Overweight or ObesityNCT07557953 · Recruiting · Phase 1 · started 2026-04-30Understanding the Effect of CagriSema, Cagrilintide, and Semaglutide on Muscle Health (Role of Amylin Signature in Muscle Health)NCT07527195 · Recruiting · Phase 1 · started 2026-04-10A Study Looking at How Weekly Injections of Two Hormones - GIP and Amylin - Affect Stomach-related Side Effects in People Who Are Overweight or ObeseNCT07411560 · Recruiting · Phase 1 · started 2026-02-09

Balanced coverage

Primary data for your own interpretation: published studies and regulator documents. No publisher opinion pieces.

Amylin and the renin-angiotensin system: risk or opportunity in amylin-based therapy?Lancet · 2025 Nov 6 · Muskiet MHA et al. · PubMedGastrointestinal adverse effects of GLP-1 receptor agonists and dual GIP/GLP-1 receptor agonists: A narrative expert review of approved therapies, oral formulations, and pipeline agents.Nutr Clin Pract · 2026 Oct · Singhani V et al. · PubMedBeyond GLP-1: Amylin-based pharmacotherapy and the search for better-tolerated weight-loss drugs.Pharmacol Res · 2026 Aug 12 · Fischer SL et al. · PubMedEfficacy and Safety of CagriSema for Metabolic Outcomes: Systematic Review and Pairwise Meta-Analysis of Randomized Controlled Trials.Diabetes Metab Syndr Obes · 2026 Sep 15 · Shao C et al. · PubMedRecent Studies on the Effectiveness and Safety of Anti-Obesity Medications: A Scoping Review.Diabetes Metab Syndr Obes · 2026 Sep 2 · Puspitasari IM et al. · PubMedEfficacy and Safety of Glucagon-like Peptide-1 Receptor Agonists and Co-agonists for Weight Loss Among Adults Without Diabetes : An Updated Systematic Review.Ann Intern Med · 2026 Sep 1 · Moiz A et al. · PubMedWeight Loss, Obesity Medication, and Risk of Obesity-Associated Cancer: A Meta-Analysis of Randomized Controlled Trials.Obesity (Silver Spring) · 2025 Nov 4 · Li C et al. · PubMedComparative efficacy and safety of glucagon-like peptide 1 based drugs for weight loss in adults with overweight or obesity without diabetes: network meta-analysis of randomised controlled trials.BMJ Med · 2026 Aug 27 · Chen D et al. · PubMedBenefits and Harms of Pharmacologic Treatments in Adults With Overweight or Obesity: A Living Systematic Review and Network Meta-analysis for the American College of Physicians.Ann Intern Med · 2026 Jun 16 · Damen JAA et al. · PubMedEfficacy and safety of once-weekly cagrilintide-semaglutide (CagriSema) in adults with type 2 diabetes inadequately controlled on diet and exercise (REIMAGINE 1): a randomised, double-blind, placebo-controlled, phase 3a study.Lancet Diabetes Endocrinol · 2026 Jun 7 · Aroda VR et al. · PubMedAsk Tina for links to further coverage

Tina is an AI research guide who has read the published research collected here and shares it as objectively as she can, for free. She's not a doctor and doesn't give medical advice.

Search the sources yourself

PubMed: CagrilintideU.S. National Library of MedicineClinicalTrials.gov: CagrilintideU.S. National Library of Medicine

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