ARA-290 / cibinetide

Published research on ARA-290 / cibinetide: record counts, recent publications, reviews and registered studies, pulled from PubMed and ClinicalTrials.gov. Part of cognitive and neurological research.

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Tina is an AI research guide who has read the published research collected here and shares it as objectively as she can, for free. She's not a doctor and doesn't give medical advice.

At a glance

36PubMed records

4Registered studies on ClinicalTrials.gov

3Randomized controlled trials

4Clinical trials

6Reviews

2Systematic reviews

Registered studies by status: 1 recruiting, 0 active not recruiting, 1 completed.

PubMed records by year

Number of PubMed records mentioning ARA-290 / cibinetide, 2016 to 2026 (2026 is year to date).

1617181920212223242526

Latest publications

Peptides in Regenerative Medicine: A Comprehensive Review of Clinical Applications in Tissue Repair and Chronic Pain Management.Curr Pain Headache Rep · 2026 Aug 24 · Luansritisakul C et al. · PubMed Immunometabolic dysregulation drives selective executive cognitive dysfunction in male db/db mice.Neurobiol Dis · 2026 Apr 1 · Alasousi D et al. · PubMed Phase-targeted erythropoietin derivatives for traumatic brain injury: bridging mechanisms to precision therapy.Front Neurol · 2026 Jan 23 · Sun Y et al. · PubMed A small erythropoietin derived non-hematopoietic peptide reduces cardiac inflammation, attenuates age associated declines in heart function and prolongs healthspan.Front Cardiovasc Med · 2023 Jan 18 · Winicki NM et al. · PubMed Early monocyte modulation by the non-erythropoietic peptide ARA 290 decelerates AD-like pathology progression.Brain Behav Immun · 2021 Jul 31 · Al-Onaizi MA et al. · PubMed The Non-Erythropoietic EPO Analogue Cibinetide Inhibits Osteoclastogenesis In Vitro and Increases Bone Mineral Density in Mice.Int J Mol Sci · 2021 Dec 21 · Awida Z et al. · PubMed Synthesis and evaluation of (99m)Tc-DOTA-ARA-290 as potential SPECT tracer for targeting cardiac ischemic region.Iran J Basic Med Sci · 2021 Nov · Mohtavinejad N et al. · PubMed The time to develop treatments for diabetic neuropathy.Expert Opin Investig Drugs · 2021 Jan 11 · Rendell MS · PubMed Cibinetide Protects Isolated Human Islets in a Stressful Environment and Improves Engraftment in the Perspective of Intra Portal Islet Transplantation.Cell Transplant · 2021 Jan-Dec · Yao M et al. · PubMed Improvement of Islet Allograft Function Using Cibinetide, an Innate Repair Receptor Ligand.Transplantation · 2020 Oct · Yao M et al. · PubMed A Phase 2 Clinical Trial on the Use of Cibinetide for the Treatment of Diabetic Macular Edema.J Clin Med · 2020 Jul 14 · Lois N et al. · PubMed The vasoreparative potential of endothelial colony-forming cells in the ischemic retina is enhanced by cibinetide, a non-hematopoietic erythropoietin mimetic.Exp Eye Res · 2019 Mar 12 · O'Leary OE et al. · PubMed

Reviews

Peptides in Regenerative Medicine: A Comprehensive Review of Clinical Applications in Tissue Repair and Chronic Pain Management.Curr Pain Headache Rep · 2026 Aug 24 · Luansritisakul C et al. · PubMed Phase-targeted erythropoietin derivatives for traumatic brain injury: bridging mechanisms to precision therapy.Front Neurol · 2026 Jan 23 · Sun Y et al. · PubMed The time to develop treatments for diabetic neuropathy.Expert Opin Investig Drugs · 2021 Jan 11 · Rendell MS · PubMed Managing fatigue in sarcoidosis - A systematic review of the evidence.Chron Respir Dis · 2016 Aug 9 · Atkins C et al. · PubMed Flipping the molecular switch for innate protection and repair of tissues: Long-lasting effects of a non-erythropoietic small peptide engineered from erythropoietin.Pharmacol Ther · 2015 Feb 26 · Collino M et al. · PubMed ARA 290 for treatment of small fiber neuropathy in sarcoidosis.Expert Opin Investig Drugs · 2014 Feb 21 · van Velzen M et al. · PubMed

Clinical trial publications

Cibinetide Improves Corneal Nerve Fiber Abundance in Patients With Sarcoidosis-Associated Small Nerve Fiber Loss and Neuropathic Pain.Invest Ophthalmol Vis Sci · 2017 May 1 · Culver DA et al. · PubMed ARA 290, a nonerythropoietic peptide engineered from erythropoietin, improves metabolic control and neuropathic symptoms in patients with type 2 diabetes.Mol Med · 2015 Mar 13 · Brines M et al. · PubMed ARA 290 improves symptoms in patients with sarcoidosis-associated small nerve fiber loss and increases corneal nerve fiber density.Mol Med · 2013 Nov 8 · Dahan A et al. · PubMed

Registered studies

Most recently started of 4 ClinicalTrials.gov entries.

Cross-cultural Adaptation and Validity of the Arabic-translated NEUROPATHY-SPECIFIC QUALITY OF LIFE QuestionnaireNCT06483620 · Recruiting · started 2025-02-13 The Use of ARA290 for the Treatment of Diabetic Macular OedemaNCT06626971 · Terminated · Phase 2 · started 2016-04 Study of Efficacy of ARA 290 on Corneal Nerve Fiber Density and Neuropathic Symptoms of Subjects With SarcoidosisNCT02039687 · Completed · Phase 2 · started 2014-01 ARA290 in T2D (Effects of ARA 290, an Erythropoietin Analogue) in Prediabetes and Type 2 Diabetes)NCT01933529 · Unknown · Phase 2 · started 2013-10

Balanced coverage

Primary data for your own interpretation: published studies and regulator documents. No publisher opinion pieces.

Pharmacological Management of Diabetic Neuropathy: Current Evidence, Clinical Positioning, and Emerging Therapeutic Targets.Curr Neuropharmacol · 2026 Aug 22 · Alburghaif AH et al. · PubMed Mechanistic Approach for Protective Effect of ARA290, a Specific Ligand for the Erythropoietin/CD131 Heteroreceptor, against Cisplatin-Induced Nephrotoxicity, the Involvement of Apoptosis and Inflammation Pathways.Inflammation · 2022 Sep 10 · Ghassemi-Barghi N et al. · PubMed An engineered non-erythropoietic erythropoietin-derived peptide, ARA290, attenuates doxorubicin induced genotoxicity and oxidative stress.Toxicol In Vitro · 2020 Apr 23 · Shokrzadeh M et al. · PubMed Detecting peptidic drugs, drug candidates and analogs in sports doping: current status and future directions.Expert Rev Proteomics · 2014 Nov 8 · Thevis M et al. · PubMed Safety and efficacy of ARA 290 in sarcoidosis patients with symptoms of small fiber neuropathy: a randomized, double-blind pilot study.Mol Med · 2012 Nov 15 · Heij L et al. · PubMed Ask Tina for links to further coverage