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TB-500 / Thymosin beta-4

Published research on TB-500 / Thymosin beta-4: record counts, recent publications, reviews and registered studies, pulled from PubMed and ClinicalTrials.gov. Part of tissue repair research.

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Tina is an AI research guide who has read the published research collected here and shares it as objectively as she can, for free. She's not a doctor and doesn't give medical advice.

At a glance

624PubMed records
18Registered studies on ClinicalTrials.gov
3Randomized controlled trials
4Clinical trials
69Reviews
0Systematic reviews

Registered studies by status: 2 recruiting, 0 active not recruiting, 11 completed.

PubMed records by year

Number of PubMed records mentioning TB-500 / Thymosin beta-4, 2016 to 2026 (2026 is year to date).

1617181920212223242526

Latest publications

Understanding the effects of ciprofloxacin on corneal epithelial cells: a study using electric cell-substrate impedance sensing (ECIS) technology.Exp Eye Res · 2026 Jul 10 · Banga L et al. · PubMedPeptides in Regenerative Medicine: A Comprehensive Review of Clinical Applications in Tissue Repair and Chronic Pain Management.Curr Pain Headache Rep · 2026 Aug 24 · Luansritisakul C et al. · PubMedPeptide Supplements and Their Therapeutic Applications in Sports Medicine.Am J Sports Med · 2026 Aug 11 · Tewari K et al. · PubMedEffects of BPC-157 and TB-500 on Achilles tendon healing in rats: A histopathological and biomechanical study.Jt Dis Relat Surg · 2026 Jul 23 · Biçer O et al. · PubMedPEGylated thymosin β4 is a thiol-site-specific prodrug treating myocardial infarction in vivo.Bioeng Transl Med · 2026 Mar 31 · Peng H et al. · PubMedEffects of Supplementation in Masters Athletes and Older Adults: A Narrative Review.Curr Sports Med Rep · 2026 Jul 1 · Nguyen C et al. · PubMedDysregulation of circulating damage-associated molecular patterns in diabetic foot syndrome.Front Immunol · 2026 Jun 22 · Uyy E et al. · PubMedReparative Outcomes in Corneal Infection: Linking Adjunctive Tβ4 Treatment to Nerve Regeneration and Visual Function.Invest Ophthalmol Vis Sci · 2026 Jun 1 · Ebrahim AS et al. · PubMedTherapeutic peptides in gerontology: mechanisms and applications for healthy aging.Front Aging · 2026 Apr 7 · Mavrych V et al. · PubMedComparative Proteomic Analysis of the Secretome of Control and BRAF/MEK Inhibitor-Resistant Melanoma Cells.J Proteome Res · 2026 Feb 25 · Simiczyjew A et al. · PubMedPeptide Therapies in Thyroid Health: Emerging Applications in Endocrine and Immune Modulation.Integr Med (Encinitas) · 2026 Apr · Mazza AD · PubMedA revised model of nuclear actin import: Importin 9 competes with cofilin, profilin, and RanGTP for actin binding.J Biol Chem · 2025 Dec 30 · Keplinger AJ et al. · PubMed

Reviews

Peptides in Regenerative Medicine: A Comprehensive Review of Clinical Applications in Tissue Repair and Chronic Pain Management.Curr Pain Headache Rep · 2026 Aug 24 · Luansritisakul C et al. · PubMedEffects of Supplementation in Masters Athletes and Older Adults: A Narrative Review.Curr Sports Med Rep · 2026 Jul 1 · Nguyen C et al. · PubMedTherapeutic peptides in gerontology: mechanisms and applications for healthy aging.Front Aging · 2026 Apr 7 · Mavrych V et al. · PubMedPeptide Therapies in Thyroid Health: Emerging Applications in Endocrine and Immune Modulation.Integr Med (Encinitas) · 2026 Apr · Mazza AD · PubMedTherapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.J Am Acad Orthop Surg Glob Res Rev · 2026 Jan 2 · Rahman OF et al. · PubMedThymosin beta 4: An emerging therapeutic candidate for kidney diseases.Peptides · 2026 Jan 20 · Di H et al. · PubMedInjectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians.Am J Sports Med · 2026 Jan 1 · Mayfield CK et al. · PubMedThymosin β(4) and β(10) Expression in Human Organs during Development: A Review.Cells · 2024 Jun 27 · Faa G et al. · PubMed

Clinical trial publications

Logistic regression analysis of environmental and other variables and incidences of tuberculosis in respiratory patients.Sci Rep · 2020 Dec 14 · Pathak AK et al. · PubMedThe effect of thymosin treatment of venous ulcers.Ann N Y Acad Sci · 2010 Apr · Guarnera G et al. · PubMed

Registered studies

Most recently started of 18 ClinicalTrials.gov entries.

Recombinant Human Thymosin Beta 4 for Injection(NL005) for Acute Myocardial InfarctionNCT07586865 · Not Yet Recruiting · Phase 2 · started 2026-05-18TB-500 (Thymosin Beta 4 17-23 Fragment) for Cardiovascular Biomarkers in Stable ASCVDNCT07487363 · Recruiting · Phase 1 / Phase 2 · started 2026-02-05Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2NCT05555589 · Recruiting · Phase 3 · started 2023-04-11Efficacy and Safety Study of Thymosin Beta 4 in Patients With Acute Myocardial InfarctionNCT05984134 · Completed · Phase 2 · started 2022-07-15Safety and Efficacy Study of Thymosin Beta 4 in Patients With Acute Myocardial Infarction.InfarctionNCT05485818 · Completed · Phase 2 · started 2020-11-23A Study of the Safety and Efficacy of Injectable Thymosin Beta 4 for Treating Acute Myocardial InfarctionNCT01311518 · Withdrawn · Phase 2 · started 2019-07Assessment of the Safety and Efficacy of RGN-259 Ophthalmic Solutions for Dry Eye Syndrome: ARISE-3NCT03937882 · Completed · Phase 3 · started 2019-05-24A Phase 1b Study of Thymosin Beta 4 in Healthy VolunteersNCT04555850 · Completed · Phase 1 · started 2018-07-30A Phase 1a Study of Thymosin Beta 4 in Healthy VolunteersNCT04555824 · Completed · Phase 1 · started 2017-07-17Assessment of the Safety and Efficacy of RGN-259 Ophthalmic Solutions for Dry Eye Syndrome : ARISE-2NCT02974907 · Completed · Phase 3 · started 2016-11Assessment of the Safety and Efficacy of RGN-259 Ophthalmic Solutions for Dry Eye Syndrome: ARISE-1NCT02597803 · Completed · Phase 2 / Phase 3 · started 2015-09Safety and Efficacy of Thymosin Beta 4 Ophthalmic Solution in Patients With Dry EyeNCT01387347 · Completed · Phase 2 · started 2011-08

Balanced coverage

Primary data for your own interpretation: published studies and regulator documents. No publisher opinion pieces.

Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance.Sports Med · 2026 Apr 12 · Mendias CL et al. · PubMedDangers of Injectable Peptides and Other Unregulated "Biohacking" Drugs.Mo Med · 2026 Jul-Aug · Moiz A et al. · PubMedSynthetic Peptides in Pharmacy Compounding: Analysis of PCAC Recommendations and Industry Safety Standards.Int J Pharm Compd · 2026 Jul-Aug · Willis J et al. · PubMedEquine Doping Controls of Thymosin β 4: A Population Study and Strategy for Misuse Detection.Drug Test Anal · 2024 Sep 24 · Delcourt V et al. · PubMedThymosin beta-4 and venous ulcers: clinical remarks on a European prospective, randomized study on safety, tolerability, and enhancement on healing.Ann N Y Acad Sci · 2007 May 10 · Guarnera G et al. · PubMedAsk Tina for links to further coverage

Tina is an AI research guide who has read the published research collected here and shares it as objectively as she can, for free. She's not a doctor and doesn't give medical advice.

Search the sources yourself

PubMed: TB-500 / Thymosin beta-4U.S. National Library of MedicineClinicalTrials.gov: TB-500 / Thymosin beta-4U.S. National Library of Medicine

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