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GHK-Cu

Published research on GHK-Cu: record counts, recent publications, reviews and registered studies, pulled from PubMed and ClinicalTrials.gov. Part of tissue repair research.

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Tina is an AI research guide who has read the published research collected here and shares it as objectively as she can, for free. She's not a doctor and doesn't give medical advice.

At a glance

82PubMed records
3Registered studies on ClinicalTrials.gov
1Randomized controlled trials
1Clinical trials
13Reviews
0Systematic reviews

Registered studies by status: 1 recruiting, 0 active not recruiting, 1 completed.

PubMed records by year

Number of PubMed records mentioning GHK-Cu, 2016 to 2026 (2026 is year to date).

1617181920212223242526

Latest publications

Hierarchical regulation and mechanism of "open-hollow-fibrous network" structures: Osteogenic-angiogenic coupling responses of poly(γ-benzyl-L-glutamate) microspheres.Biomater Adv · 2026 Jun 15 · Su J et al. · PubMedA tea exosome-integrated self‑oxygenating cascade chitosan/oxidized alginate hydrogel for remodeling the hyperglycemic and hypoxic microenvironment in diabetic wound healing.Carbohydr Polym · 2026 Jul 8 · Xie LH et al. · PubMedMicroenvironment-responsive injectable dynamic hydrogel for sequential antioxidant and tissue regeneration therapy of radiation-induced skin injury.Bioact Mater · 2026 Apr 21 · Yu X et al. · PubMedGHK-Cu as a Bioactive Metallopeptide and Drug-Delivery Cargo: Coordination Chemistry, Formulation Science, Therapeutic Evidence, and a Translational Roadmap.Pharmaceutics · 2026 Aug 27 · Mateescu DM et al. · PubMedPeptides in Regenerative Medicine: A Comprehensive Review of Clinical Applications in Tissue Repair and Chronic Pain Management.Curr Pain Headache Rep · 2026 Aug 24 · Luansritisakul C et al. · PubMedThe Regenerative Potential of GHK-Cu in Aesthetic Medicine.Aesthet Surg J · 2026 Aug 20 · Mokhtar J et al. · PubMedPeptide Supplements and Their Therapeutic Applications in Sports Medicine.Am J Sports Med · 2026 Aug 11 · Tewari K et al. · PubMedAugmented Skin Beneficial Effects of Thermus Thermophilus and Bacillus Subtilis Mixed-Culture Ferment Extract by Tripeptide GHK-Cu.Skin Res Technol · 2026 Aug · Wang J et al. · PubMedCopper peptide activated cascade catalysis for glucose regulation and hypoxia reversing in infected diabetic wound healing.Mater Today Bio · 2026 Jun 26 · Huang ZJ et al. · PubMedA Systematic Review of the Mechanisms and Therapeutic Applications of GHK-Cu (Glycyl-L-Histidyl-L-Lysine-Copper Complex) in Topical Microneedle Delivery: A Case for Expanded Clinical Trials.Arch Intern Med Res · 2026 Aug 29 · Najafi N et al. · PubMedA Torilis japonica Extract-GHK-Cu Complex Attenuates Th2 Cytokines and Promotes Keratinocyte Recovery: A Potential Antioxidant Strategy for Atopic Dermatitis.Antioxidants (Basel) · 2026 Jun 29 · Jeon S et al. · PubMedMiddle-aged mice treated with GHK-Cu peptide administered intraperitoneally or intranasally show behavioral rescue but divergent hippocampal aging programs.Res Sq · 2026 May 26 · Mazzola J et al. · PubMed

Reviews

GHK-Cu as a Bioactive Metallopeptide and Drug-Delivery Cargo: Coordination Chemistry, Formulation Science, Therapeutic Evidence, and a Translational Roadmap.Pharmaceutics · 2026 Aug 27 · Mateescu DM et al. · PubMedPeptides in Regenerative Medicine: A Comprehensive Review of Clinical Applications in Tissue Repair and Chronic Pain Management.Curr Pain Headache Rep · 2026 Aug 24 · Luansritisakul C et al. · PubMedTherapeutic peptides in gerontology: mechanisms and applications for healthy aging.Front Aging · 2026 Apr 7 · Mavrych V et al. · PubMedTherapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.J Am Acad Orthop Surg Glob Res Rev · 2026 Jan 2 · Rahman OF et al. · PubMedSmart Healing for Wound Repair: Emerging Multifunctional Strategies in Personalized Regenerative Medicine and Their Relevance to Orthopedics.Antibiotics (Basel) · 2026 Jan 1 · Arciola CR et al. · PubMedInjectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians.Am J Sports Med · 2026 Jan 1 · Mayfield CK et al. · PubMedTopically applied GHK as an anti-wrinkle peptide: Advantages, problems and prospective.Bioimpacts · 2024 Apr 28 · Mortazavi SM et al. · PubMedAre We Ready to Measure Skin Permeation of Modern Antiaging GHK-Cu Tripeptide Encapsulated in Liposomes?Molecules · 2025 Jan 1 · Ogórek K et al. · PubMed

Clinical trial publications

Effects of topical copper tripeptide complex on CO2 laser-resurfaced skin.Arch Facial Plast Surg · 2006 Jul-Aug · Miller TR et al. · PubMed

Registered studies

Most recently started of 3 ClinicalTrials.gov entries.

Two-Part Study of the Effects of the X39 Patch on Circulating GHK and GHK-Cu Levels in Healthy AdultsNCT07706361 · Not Yet Recruiting · NA · started 2027-01Topical GHK-Cu Gel for Acute Skin Wound HealingNCT07437586 · Recruiting · Phase 2 · started 2026-02-02Trial Assessing the Impact on Facial Skin Quality, Hydration, and Skin Barrier of Three (3) Hydrafacial Treatments in Adults of All Skin Types.NCT05932732 · Completed · Phase 4 · started 2023-11-20

Balanced coverage

Primary data for your own interpretation: published studies and regulator documents. No publisher opinion pieces.

Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance.Sports Med · 2026 Apr 12 · Mendias CL et al. · PubMedTherapeutic Peptides in Aesthetic, Metabolic and Endocrine Conditions: Effects, Safety, Clinical Applications, and Future Perspectives.Int J Mol Sci · 2026 Apr 27 · Renke G et al. · PubMedAsk Tina for links to further coverage

Tina is an AI research guide who has read the published research collected here and shares it as objectively as she can, for free. She's not a doctor and doesn't give medical advice.

Search the sources yourself

PubMed: GHK-CuU.S. National Library of MedicineClinicalTrials.gov: GHK-CuU.S. National Library of Medicine

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