GHRP-6

Published research on GHRP-6: record counts, recent publications, reviews and registered studies, pulled from PubMed and ClinicalTrials.gov. Part of growth hormone axis research.

Ask Tina

Tina is an AI research guide who has read the published research collected here and shares it as objectively as she can, for free. She's not a doctor and doesn't give medical advice.

At a glance

680PubMed records

0Registered studies on ClinicalTrials.gov

20Randomized controlled trials

43Clinical trials

28Reviews

0Systematic reviews

Registered studies by status: 0 recruiting, 0 active not recruiting, 0 completed.

PubMed records by year

Number of PubMed records mentioning GHRP-6, 2016 to 2026 (2026 is year to date).

1617181920212223242526

Latest publications

Phase III Open-Label, Randomized Clinical Trial of Epidermal Growth Factor and Growth Hormone Releasing Hexapeptide in Acute Ischemic Stroke.J Clin Neurosci · 2026 Jul 16 · Hernández-Bernal F et al. · PubMed Ghrelin Receptor Blockade Restricts Hepatic Echinococcus granulosus Infection by Suppressing Host Cell Proliferation and Enhancing Fibrotic Encapsulation.Acta Parasitol · 2026 Sep 26 · Chen G et al. · PubMed Ghrelin attenuates hypoxia-induced mitochondrial oxidative stress damage in HTR-8/SVneo trophoblasts.Tissue Cell · 2026 Sep 10 · Feng W et al. · PubMed A discovery-based proteomic approach of epidermal growth factor and growth hormone-releasing peptide-6 in a model of acute ischemic stroke.Pharmacol Rep · 2026 Jun 8 · Rodríguez-Ulloa A et al. · PubMed EGF and GHRP6 Co-Administration Attenuates Cognitive Decline in Preclinical Models: Behavioral and Molecular Evidences.Neurotox Res · 2026 Jul 4 · Risco-Acevedo D et al. · PubMed Ghrelin impairs embryo development after ovarian hyperstimulation.J Endocrinol · 2026 Jul 1 · Ramírez ND et al. · PubMed The Ghrelin/GHSR-1a Axis Attenuates Preeclampsia-like Features with Decidual Macrophage Reprogramming and Improved Placental Remodeling.Biomolecules · 2026 May 29 · Zhang L et al. · PubMed Growth Hormone-Releasing Peptide-6 (GHRP-6) Ameliorates Post-Infarct Ventricular Remodeling and Systolic Dysfunction in a Model of Permanent Coronary Ligation.Pharmaceuticals (Basel) · 2026 Mar 12 · Wang L et al. · PubMed Growth hormone releasing peptide-6 (GHRP-6) ameliorates acute lung injury and its subsequent evolvement to interstitial fibrosis.Int Immunopharmacol · 2026 Jan 13 · Wang L et al. · PubMed Effect of intracerebroventricular (ICV) injection of antimicrobial peptide expressed in the body-2 (LEAP-2) and its interaction with cannabinoid and ghrelin systems on food intake in broiler chickens.Poult Sci · 2025 Dec 6 · Rahmania A et al. · PubMed Oral salmon acylated ghrelin increases food intake in common carp (Cyprinus carpio) via ghrelin receptors, likely through sensory nerves rather than systemic absorption.Peptides · 2026 Jan 9 · Kihara M et al. · PubMed Growth hormone-releasing peptide 6 (GHRP-6) hydrogel for acute kidney injury therapy via metabolic regulation.J Nanobiotechnology · 2025 Dec 1 · Zhao X et al. · PubMed

Reviews

Assessing the role of ghrelin and the enzyme ghrelin O-acyltransferase (GOAT) system in food reward, food motivation, and binge eating behavior.Pharmacol Res · 2021 Aug 24 · Micioni Di Bonaventura E et al. · PubMed Synthesis and Biomedical Potential of Azapeptide Modulators of the Cluster of Differentiation 36 Receptor (CD36).Biomedicines · 2020 Jul 23 · Proulx C et al. · PubMed Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males.Transl Androl Urol · 2020 Mar · Sinha DK et al. · PubMed Water-in-oil microemulsions for effective transdermal delivery of proteins.Expert Opin Drug Deliv · 2011 Mar 18 · Russell-Jones G et al. · PubMed Diagnosis of adult GH deficiency.Growth Horm IGF Res · 2007 Sep 4 · Ghigo E et al. · PubMed Diagnosis of adult GH deficiency.Pituitary · 2008 · Gasco V et al. · PubMed Growth hormone levels in the diagnosis of growth hormone deficiency in adulthood.Pituitary · 2007 · Corneli G et al. · PubMed Physiology of ghrelin and related peptides.Domest Anim Endocrinol · 2005 Apr 18 · Anderson LL et al. · PubMed

Clinical trial publications

Phase III Open-Label, Randomized Clinical Trial of Epidermal Growth Factor and Growth Hormone Releasing Hexapeptide in Acute Ischemic Stroke.J Clin Neurosci · 2026 Jul 16 · Hernández-Bernal F et al. · PubMed Insulinotropic action of bombesin-like peptides mediated by gastrin-releasing peptide receptors in steers.J Anim Sci · 2016 Jan · Zhao HQ et al. · PubMed Bombesin-like peptides stimulate growth hormone secretion mediated by the gastrin-releasing peptide receptor in cattle.Peptides · 2012 Jul 31 · Zhao H et al. · PubMed Effects of ghrelin, GH-releasing peptide-6 (GHRP-6) and GHRH on GH, ACTH and cortisol release in hyperthyroidism before and after treatment.Pituitary · 2010 Dec · Molica P et al. · PubMed Effects of ghrelin, growth hormone-releasing peptide-6, and growth hormone-releasing hormone on growth hormone, adrenocorticotropic hormone, and cortisol release in type 1 diabetes mellitus.Metabolism · 2010 Mar 1 · de Sá LB et al. · PubMed Diagnosis of adrenal insufficiency using the GHRP-6 Test: comparison with the insulin tolerance test in patients with hypothalamic-pituitary-adrenal disease.Horm Metab Res · 2009 Nov 27 · Alaioubi B et al. · PubMed Adrenocorticotrophic hormone (ACTH) responsiveness to ghrelin increases after 6 months of ketoconazole use in patients with Cushing's disease: comparison with GH-releasing peptide-6 (GHRP-6).Clin Endocrinol (Oxf) · 2009 Apr 29 · Correa-Silva SR et al. · PubMed Association between tumoral GH-releasing peptide receptor type 1a mRNA expression and in vivo response to GH-releasing peptide-6 in ACTH-dependent Cushing's syndrome patients.Eur J Endocrinol · 2008 May · Machado MC et al. · PubMed

Balanced coverage

Primary data for your own interpretation: published studies and regulator documents. No publisher opinion pieces.

The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration.Front Endocrinol (Lausanne) · 2026 Jun 18 · Dominikowski A et al. · PubMed Ghrelin Improves Glucolipotoxicity-Induced Pancreatic β-Cellular Dysfunction and Apoptosis by Inhibiting Endoplasmic Reticulum Stress-Induced IRE1/JNK Pathway.Discov Med · 2024 Jul · Li XY et al. · PubMed In-house standards derived from doping peptides: Enzymatic and serum stability and degradation profile of GHRP and GHRH-related peptides.Biomed Chromatogr · 2023 Sep 9 · González-López NM et al. · PubMed Pharmacokinetic study of Growth Hormone-Releasing Peptide 6 (GHRP-6) in nine male healthy volunteers.Eur J Pharm Sci · 2012 Oct 23 · Cabrales A et al. · PubMed Ghrelin and GHRP-6-induced ACTH and cortisol release in thyrotoxicosis.Pituitary · 2009 Apr 26 · Nascif SO et al. · PubMed Decreased ghrelin-induced GH release in thyrotoxicosis: comparison with GH-releasing peptide-6 (GHRP-6) and GHRH.Pituitary · 2007 · Nascif SO et al. · PubMed Ask Tina for links to further coverage